I agree with jkosten regarding gearing. I have been running my 33's for close to three years on stock 4.10's. I would NOT recommend this to anyone if it can be avoided. I do have the benefit of getting 24mpg on the highway now, but at the expense of barely having a 5th gear (i.e. no power) and a large loss of power in my lower gears.
My truck has the 22RE, 5-spd transmission, and originally came with 225/75/15 tires so your gearing may be different. I need to switch to 4.88's to get back my lost power and correct my speedo. I have the gears sitting in the garage and am just waiting until I find a shop I trust and can arrange the work.